If an entity is going to be immutable, the question of whether to use a struct or a class will generally be one of performance rather than semantics. On a 32/64-bit system, class references require 4/8 bytes to store, regardless of the amount of information in the class; copying a class reference will require copying 4/8 bytes. On the other hand, every distinct class instance will have 8/16 bytes of overhead in addition to the information it holds and the memory cost of the references to it. Suppose one wants an array of 500 entities, each holding four 32-bit integers. If the entity is a structure type, the array will require 8,000 bytes regardless of whether all 500 entities are all identical, all different, or somewhere between. If the entity is a class type, the array of 500 references will take 4,000 bytes. If those references all point to different objects, the objects would require an additional 24 bytes each (12,000 bytes for all 500), a total of 16,000 bytes--twice the storage cost of a struct type. On the other hand, of the code created one object instance and then copied a reference to all 500 array slots, the total cost would be 24 bytes for that instance and 4,000 for the array--a total of 4,024 bytes. A major savings. Few situations would work out as well as the last one, but in some cases it may be possible to copy some references to enough array slots to make such sharing worthwhile.
If the entity is supposed to be mutable, the question of whether to use a class or struct is in some ways easier. Assume "Thing" is either a struct or class which has an integer field called x, and one does the following code:
Thing t1,t2;
...
t2 = t1;
t2.x = 5;
Does one want the latter statement to affect t1.x?
If Thing is a class type, t1 and t2 will be equivalent, meaning t1.x and t2.x will also be equivalent. Thus, the second statement will affect t1.x. If Thing is a structure type, t1 and t2 will be different instances, meaning t1.x and t2.x will refer to different integers. Thus, the second statement will not affect t1.x.
Mutable structures and mutable classes have fundamentally different behaviors, though .net has some quirks in its handling of struct mutations. If one wants value-type behavior (meaning that "t2=t1" will copy the data from t1 to t2 while leaving t1 and t2 as distinct instances), and if one can live with the quirks in .net's handling of value types, use a structure. If one wants value-type semantics but .net's quirks would cause lead to broken value-type semantics in one's application, use a class and mumble.