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andrew_ramirez[andrew_ramirez['Datacenter'].isin(['ATL2','ACT1'])]['payout']*= 0.25

This is not changing my dataframe (named andrew_ramirez) based on the criteria. Am i missing something?

Please clarify your specific problem or provide additional details to highlight exactly what you need. As it's currently written, it's hard to tell exactly what you're asking. - Community