Currently using CKEditor + IMCE.
Are there better alternatives for a Drupal rich-text editor with image upload support?
To set it up, I add the modules, enable them, add the CKEditor source, configure the Default CKEditor profile to not load unless I tell it to, disable security filters until it loads, and enable the Drupal - Full toolbar version. This gives me all the CKEditor features and flexibility, image and flash upload support via IMCE.
I have tried CKFinder, but I rarely use it on client projects (non-free usage licences). Other modules are a pain to configure and may sometimes break the interface or content (especially around full HTML or PHP inputs).
Update 1: Added a small bounty, looking for more answers.