OK, I get all the methods and thinking behind responsive design, I've created and mucked about with media queries and I know how to change image sizes based upon all of this with the css max-width: 100%; rule.
One thing that is bothering me that i cant seem to get my head around is this. When Im uploading images to WordPress for use inside my responsive theme, what sizes should they be? Do I need to define the images sizes as I would for a static site, or do I just upload the largest image size that I want to use and let the max-width take care of resizing everything for thumbnails etc.