Currently, you are dealing with the Outlook object model, not MAPI.
Outlook is a singleton, you can't run two instances on the system at the same time. So, when you create a new Application
instance you will be linked to the already running instance. Be aware, you need to run both applications under the same security context.
Note, Microsoft does not currently recommend, and does not support, Automation of Microsoft Office applications from any unattended, non-interactive client application or component (including ASP, ASP.NET, DCOM, and NT Services), because Office may exhibit unstable behavior and/or deadlock when Office is run in this environment.
If you are building a solution that runs in a server-side context, you should try to use components that have been made safe for unattended execution. Or, you should try to find alternatives that allow at least part of the code to run client-side. If you use an Office application from a server-side solution, the application will lack many of the necessary capabilities to run successfully. Additionally, you will be taking risks with the stability of your overall solution. Read more about that in the Considerations for server-side Automation of Office article.
As a workaround, you may consider using Open XML SDK if you deal only with Exchange accounts, see Start using web services in Exchange for more information.