Such an easy answer for that question? Never mind! Please read carefully before answering that by Google.
Today I faced an Office 365 installed in such weird way, that was installed in this location: C:\Program Files\WindowsApps\Microsoft.Office.Desktop.Outlook_16051.11601.20204.0_x86__8wekyb3d8bbwe\Office16
I have an application that changes default signature for each account that is working from office 2000 to 2019 (on PCs excluding this one).
I'm able to change anything in the registry profile location (HKCU\SOFTWARE\Microsoft\Office\16.0\Outlook\Profiles) but it is having no effect in the installed Outlook.
I'm also unable to find currently active settings anywhere in the registry. What I'm missing?
I also post it on MS TechNet: https://social.technet.microsoft.com/Forums/office/en-US/c6742cee-4891-4a54-a5c7-81e01cc44354/outlook-2019-profile-location?forum=Office2016ITPro