It would be nice if InstallShield provided a 64bit version of their automation interface, but until then.... try this. Add a surrogate registry key for the InstallShield automation object by adding these keys. This CLSID is for IswiAuto23. If you have a different version of the InstallShield automation object installed, then search the registry for the matching InstallShield clsid and update registry accordingly.
[HKEY_CLASSES_ROOT\WOW6432Node\CLSID\{3C44313C-4B47-4C59-BA06-1398FABFCDAD}]
"AppID"="{3C44313C-4B47-4C59-BA06-1398FABFCDAD}"
[HKEY_CLASSES_ROOT\WOW6432Node\AppID\{3C44313C-4B47-4C59-BA06-1398FABFCDAD}]
"DllSurrogate"=""