The following Applescript code works (i.e. opens the document, provided it exists) with Word 2008.
It does not work with Word 2016 if the application is not already running.
tell application "Microsoft Word"
open file "Macintosh HD:Users:username:Stuff.docx"
end tell
Word 2016 opens a dialog saying that the file does not exist, then creates and opens a file in the following directory:
/Users/username/Library/Containers/com.microsoft.Word/Data
That file’s name appears as follows in the Finder:
Macintosh HD/Users/username/Stuff.docx
And as follows in the Terminal:
~$cintosh HD:Users:edimark:Rien.docx