Seems to be I can't find the proper syntax for this.
Version 1.1.4 Snapshot [cqlsh 2.2.0 | Cassandra unknown | CQL spec 3.0.0 | Thrift protocol 19.32.0]
I can create a new keyspace with the following.
create keyspace something_interesting WITH strategy_class = 'NetworkTopologyStrategy' AND strategy_options:"99999" = 3 AND strategy_options:"44444" = 3 AND strategy_options:"66666" = 3;
However ALTER KEYSPACE "something_interesting" WITH REPLICATION = {'class' : 'NetworkTopologyStrategy', "66666":1,"44444":1};
Results in a syntax error.