Your data is going to have some serious issues at some point - storing integers in text-based fields produces all sorts of problems with converting on the fly. If you can't clean that up, we need to get a little tricky and make a heap of assumptions e.g. that any NULL will defeat any numeric value.
I'm going to assume you have an ID of some sort to query on, and I'll build a little table for a demo:
CREATE TABLE mynvarcharstuff (ID INTEGER, LINE1_OPEN_LOOP_VOLTAGE nvarchar(50), LINE2_OPEN_LOOP_VOLTAGE nvarchar(50))
INSERT INTO mynvarcharstuff VALUES (1, '-49.15', '-8.68'), (2, '-49.15', NULL), (3, '-18', '7.65'), (4, '26.5', '4')
, (5, '49.15', NULL), (6, '25.3', '-12.4'), (7, NULL, NULL), (8, 'bob', '6.5'), (9, ' 33', '')
Solving the issue of converting on the fly is done using a CTE (or temp table if you like) to sort it out as you go, based on those IDs:
WITH numeric_ids AS (
SELECT ID
, CASE WHEN (LINE1_OPEN_LOOP_VOLTAGE IS NULL OR LINE2_OPEN_LOOP_VOLTAGE IS NULL) THEN 1 ELSE 0 END AS CheckNull
, CASE WHEN ISNUMERIC(LINE1_OPEN_LOOP_VOLTAGE) = 1 THEN 1 ELSE 0 END AS CheckLine1
, CASE WHEN ISNUMERIC(LINE2_OPEN_LOOP_VOLTAGE) = 1 THEN 1 ELSE 0 END AS CheckLine2
FROM mynvarcharstuff
)
SELECT N.ID
, CASE
-- If you move this line below either of the numeric checks, you potentially get errors - be careful!
WHEN I.CheckNull = 1 THEN 'NO'
WHEN (I.CheckLine1 = 1 AND CONVERT(DECIMAL(5, 2), [LINE1_OPEN_LOOP_VOLTAGE]) >= 0.0) THEN 'YES'
WHEN (I.CheckLine2 = 1 AND CONVERT(DECIMAL(5, 2), [LINE2_OPEN_LOOP_VOLTAGE]) >= 0.0) THEN 'YES'
ELSE 'CHECK BUSINESS LOGIC'
END AS 'REVERSE POLARITY ISSUE'
FROM mynvarcharstuff N
JOIN numeric_ids I ON I.ID = N.ID
As we can't convert the columns on the fly, we need to first check they're able to be converted, then see if they're positive or NULL.
Note this isn't a perfect solution. If you have rules around whether NULL must exist in Line1 if it appears in Line2 and vice-versa, it works.
But you're better off cleaning the data with something like this:
DELETE
FROM mynvarcharstuff
WHERE (ISNUMERIC(LINE1_OPEN_LOOP_VOLTAGE) = 0 AND LINE1_OPEN_LOOP_VOLTAGE IS NOT NULL)
OR (ISNUMERIC(LINE2_OPEN_LOOP_VOLTAGE) = 0 AND LINE2_OPEN_LOOP_VOLTAGE IS NOT NULL)