This issue occurs in ASP.NET 4.6 and I've seen a few similar posts, but they usually referred not to the same control (built-in here) or ended up with a conclusion "just use a different/external control here: html link", which is not really an option for me.
First, some code
Site.Master
<div id="HeaderProper">
<div id="HeaderProperTitle">
<asp:Menu ID="HeaderProperMenu" runat="server" DataSourceID="HeaderProperSiteMap" Orientation="Horizontal"
BackColor="#ff2400"
RenderingMode="List"
StaticEnableDefaultPopOutImage="false"
StaticDisplayLevels="2"
StaticHoverStyle-BackColor="#000000"
StaticMenuItemStyle-HorizontalPadding="15px"
StaticMenuItemStyle-Height="42px"
DynamicHoverStyle-BackColor="#000000"
DynamicMenuItemStyle-HorizontalPadding="5px"
DynamicMenuItemStyle-BackColor="#ff2400"
DynamicMenuItemStyle-Font-Size="24px"/>
<asp:SiteMapDataSource ID="HeaderProperSiteMap" runat="server" />
</div>
SomePage.aspx
<asp:Content ID="Content2" ContentPlaceHolderID="MainContent" runat="server">
<h1>Complete List</h1>
<div>
<asp:UpdatePanel ID="UpdatePanel1" runat="server">
<ContentTemplate>
<div class="SortOrderSelection">
Sort by
<asp:DropDownList ID="cbxSortBy" runat="server" AutoPostBack="true"
OnSelectedIndexChanged="cbxSortBy_SelectedIndexChanged" />
</div>
<asp:Panel ID="SortedList" CssClass="top-margin five-columns" runat="server" />
<asp:Panel ID="Summary" CssClass="top-margin" runat="server" />
</ContentTemplate>
</asp:UpdatePanel>
</div>
</asp:Content>
How to reproduce: Choose an item in the DropDownList, which causes partial postback. The menu then stops working, that is - the drop down/hover menu doesn't open, but the first level links seem to be functional. Refreshing the whole page fixes the problems (duh?).
And, contrary to what I've found: 1) Menu is NOT inside an UpdatePanel, which I acknowledge is unsupported solution 2) Menu works fine when RenderingMode is set to Table, but generates a very ugly html code, which I would like to avoid. Not mentioning additional quirks in margins that have to be adjusted with ugly fixes. 3) I tried setting z-index: 1000...0 !important as suggested by some sources (on most menu related styles), but to no avail.
I would be grateful for any suggestions how this can be resolved while still using asp:Menu control in List rendering mode, possibly with as least intervention as possible. My point here is to use built-in functionality and keep the code clean from unnecessary JS, jQuery (if possible at all; otherwise I'd rather open a Connect case for this issue). Thank you in advance.