OpenCL thread of execution is completely independent to your application. So there is no need to "wait" after each call. Just flush all the order to OpenCL and it should schedule them properly.
The only need is to have 2 queues, in order to be able to run commands in parallel. So you will need a IO queue, and an execution queue. A single queue (even in out of order mode), can never run 2 operations in parallel.
Here you have one example approach with events, you can call clFlush() on the queues just after doing the enqueues in order to speed them up.
//Create 2 queues (at creation only!)
mQueueIO = cl::CommandQueue(context, device[0], 0);
mQueueRun = cl::CommandQueue(context, device[0], 0);
//Everytime you run your image filter
//Queue the 2 writes
cl::Event wev1; //Event to known when the write finishes
mQueueIO.enqueueWriteBuffer(ImageBufferCL, CL_FALSE, 0, size/2, imageCPU, NULL, &wev1);
cl::Event wev2; //Event to known when the write finishes
mQueueIO.enqueueWriteBuffer(ImageBufferCL, CL_FALSE, size/2, size/2, imageCPU+size/2, &wev2);
//Queue the 2 runs (with the proper dependency)
std::vector<cl::Event> wait;
wait.push_back(wev1);
cl::Event ev1; //Event to track the finish of the run command
mQueueRun.enqueueNDRangeKernel(kernel, cl::NDRange(0), cl::NDRange(size/2), cl::NDRange(localsize), &wait, &ev1);
wait[0] = wev2;
cl::Event ev2; //Event to track the finish of the run command
mQueueRun.enqueueNDRangeKernel(kernel, cl::NDRange(size/2), cl::NDRange(size/2), cl::NDRange(localsize), &wait, &ev2);
//Read back the data when it has finished
std::vector<cl::Event> rev(2);
wait[0] = ev1;
mQueueIO.enqueueReadBuffer(ImageBufferCL, CL_FALSE, 0, size/2, imageCPU, &wait, &rev[0]);
wait[0] = ev1;
mQueueIO.enqueueReadBuffer(ImageBufferCL, CL_FALSE, size/2, size/2, imageCPU + size/2, &wait, &rev[1]);
rev[0].wait();
rev[1].wait();
Notice how I create 2 events for writing, these are the wait events of the execution; and 2 events for execution that are the wait events for reading.
In the last part I create another 2 events for reading but they are not really needed, you can use a blocking read.