Adding this for completeness and because I couldn't find it anywhere else on SO. Like @mhawke says, you can use psycopg2, but you can also use any other Python database modules (ORMs, etc) that allow you to manually specify a database postgresql URI (postgresql://[user[:password]@][netloc][:port][/dbname][?param1=value1&...]) to connect to since the sslmode="require" parameter that psycopg2.connect uses to enforce ssl connections is just part of the postgresql:// URI that you use to connect to your database (see 33.1.2. Parameter Key Words). So, if you wanted to use sqlalchemy or another ORM instead of vanilla psycopg2, you can tack your desired sslmode onto the end of your database URI and connect that way.
import sqlalchemy
DATABASE_URI = "postgresql://postgres:postgres@localhost:5432/dbname"
# sqlalchemy 1.4+ uses postgresql:// instead of postgres://
ssl_mode = "?sslmode=require"
DATABASE_URI += ssl_mode
engine = sqlalchemy.create_engine(URI)
Session = sqlalchemy.orm.sessionmaker(bind=engine)
There's a nifty figure (Table 33.1) in the postgres documentation on SSL Support that breaks down the different options you can supply. If you want to use any of the fancier options that require you to specify a path to a specific certificate, you can drop it in with a format string.
connectmethod. - bluesmoon