First, if they are actually rows in the database, you can simply create a new row containing the sums:
insert into mytable (columnA, columnB, columnC)
select sum(columnA), sum(columnB), sum(columnC) from mytable
But it's rather unusual to do that in the actual table unless you have a way of distinguishing these "totals" rows from the regular ones.
If they're columns, as appears from the layout, there are some issues.
First, what you're attempting will violate third normal form, which is rarely a good thing. You need to think of what will happen if someone changes one of the columns but doesn't also update the totals column.
But, if you want to do this, it's a simmple matter of:
update mytable set columnD = columnA + columnB + columnC