Correction: as Zubair points out, the step below disables the Google Closure optimization but does NOT eliminate Google Closure code from the final JavaScript. You should choose advanced optimization to eliminate unused JavaScript as the other answer suggests.
In ClojureScript: Up and Running, the authors explain how to disable the Google Closure step:
With an :optimizations value of :none [in project.clj], the Google Closure Compiler
will not be invoked at all, and the build will write out the
JavaScript produced by the ClojureScript compiler directly. This mode
is useful for development and debugging. However, the JavaScript
output will be split across many individual files, requiring slightly
different handling in a browser [...]
Note that this may or may not reduce the size of the produced JavaScript, since Google Closure does a fair bit of work to strip out anything your code doesn't specifically invoke. It's probably worth playing around with the various values of :optimizations (:none, :whitespace, :simple and :advanced) and seeing how big the resulting JavaScript is in each case.