You can do this easily with grep:
$ grep -Fwvf file2 file1
aaa bbb, sss,
Options:
-f FILE, --file=FILE
Obtain patterns from FILE, one per line. The empty file contains zero patterns, and therefore
matches nothing. (-f is specified by POSIX.)
-v, --invert-match
Invert the sense of matching, to select non-matching lines. (-v is specified by POSIX.)
-w, --word-regexp
Select only those lines containing matches that form whole words. The test is that the
matching substring must either be at the beginning of the line, or preceded by a non-word
constituent character. Similarly, it must be either at the end of the line or followed by a
non-word constituent character. Word-constituent characters are letters, digits, and the
underscore.
-F, --fixed-strings
Interpret PATTERN as a list of fixed strings, separated by newlines, any of which is to be
matched. (-F is specified by POSIX.)
To store the changes back to file1:
$ grep -Fwvf file2 file1 > tmp && mv tmp file1