I have posted this on the sencha forums as a bug, but I figured getting it out on stack overflow could be advantageous:
and a screenshot of it in action can be seen here:
http://www.sencha.com/forum/showthread.php?257508-Strange-behaviors-in-Chrome-25-with-Ext-4.1
Basically, with ExtJs 4.1, after upgrading to Chrome 25, our users are sporadically seeing layout failure in our application.
It usually is noticed by the window 'close' button appearing skewed on the left of a window instead of the right, and all the form fields displayed vertically. Once it happens, every subsequent component that is rendered is all messed up.
Reverting to chrome 24, or using Firefox makes the problem dissipate. The issue shows up in IE when running Chrome Frame 25.
We have disabled our custom CSS, and still seen the issue.
Any ideas?