Your question is already three years old and there are some details not covered in other answers:
Most people I know use HomeBrew or MacPorts, I prefer MacPorts because of its clean cut of what is a default Mac OS X environment and my development setup. Just move out your /opt folder and test your packages with a normal user Python environment
MacPorts is only portable within Mac, but with easy_install or pip you will learn how to setup your environment in any platform (Win/Mac/Linux/Bsd...). Furthermore it will always be more up to date and with more packages
I personally let MacPorts handle my Python modules to keep everything updated. Like any other high level package manager (ie: apt-get) it is much better for the heavy lifting of modules with lots of binary dependencies. There is no way I would build my Qt bindings (PySide) with easy_install or pip. Qt is huge and takes a lot to compile. As soon as you want a Python package that needs a library used by non Python programs, try to avoid easy_install or pip
At some point you will find that there are some packages missing within MacPorts. I do not believe that MacPorts will ever give you the whole CheeseShop. For example, recently I needed the Elixir module, but MacPorts only offers py25-elixir and py26-elixir, no py27 version. In cases like these you have:
pip-2.7 install --user elixir
( make sure you always type pip-(version) )
That will build an extra Python library in your home dir. Yes, Python will work with more than one library location: one controlled by MacPorts and a user local one for everything missing within MacPorts.
Now notice that I favor pip over easy_install. There is a good reason you should avoid setuptools and easy_install. Here is a good explanation and I try to keep away from them. One very useful feature of pip is giving you a list of all the modules (along their versions) that you installed with MacPorts, easy_install and pip itself:
pip-2.7 freeze
If you already started using easy_install, don't worry, pip can recognize everything done already by easy_install and even upgrade the packages installed with it.
If you are a developer keep an eye on virtualenv for controlling different setups and combinations of module versions. Other answers mention it already, what is not mentioned so far is the Tox module, a tool for testing that your package installs correctly with different Python versions.
Although I usually do not have version conflicts, I like to have virtualenv to set up a clean environment and get a clear view of my packages dependencies. That way I never forget any dependencies in my setup.py
If you go for MacPorts be aware that multiple versions of the same package are not selected anymore like the old Debian style with an extra python_select package (it is still there for compatibility). Now you have the select command to choose which Python version will be used (you can even select the Apple installed ones):
$ port select python
Available versions for python:
none
python25-apple
python26-apple
python27 (active)
python27-apple
python32
$ port select python python32
Add tox on top of it and your programs should be really portable