Several options depending on whether you have blanks inside your range (use method 1), or more simply if you want to find the last used cell (use method 3)
These options using column A of the activesheet as an example
1. SpecialCells
If the empty cells are truly empty then you can use SpecialCells to work with the formulae cells (that start with =) and/or constant cells
Sub GetNonEmtpy()
Dim rng1 As Range
Dim rng2 As Range
On Error Resume Next
Set rng1 = Columns("A").SpecialCells(xlConstants)
Set rng2 = Columns("A").SpecialCells(xlFormulas)
On Error GoTo 0
If Not rng1 Is Nothing Then MsgBox "Constants in " & rng1.Address(0, 0)
If Not rng2 Is Nothing Then MsgBox "formula in " & rng2.Address(0, 0)
'then work with these ranges
End Sub
2. Last cell look up
Sub LastCellLookup()
Dim rng1 As Range
Set rng1 = Cells(Rows.Count, "A").End(xlUp)
If rng1.Row <> 1 Then
MsgBox "last cell is " & rng1.Address(0, 0)
Else
'check first cell is not empty
If Len(rng1.Value) > 0 Then
MsgBox "last cell is " & rng1.Address(0, 0)
Else
MsgBox "row is blank"
End If
End If
End Sub
3. Find
Sub LastCellFind()
Dim rng1 As Range
Set rng1 = Columns("A").Find("*", [a1], xlValues, , xlByRows, xlPrevious)
If Not rng1 Is Nothing Then MsgBox "Last cell is " & rng1.Address(0, 0)
End Sub