tldr; Use 3 node cluster for both, write/read quorum.
Keep in mind: Write Consistency + Read Consistency > Replication factor to ensure that your data is consistent.
You may as well go with a 3 node cluster for both. Alternatively in your first setup (2 nodes) is the same as a 1 node 'cluster'. Because you're either writing to ALL, or your reads won't be consistent.
Setup 1:
For Setup 1 in a RF 2 you would need to:
Write(2) + Read(1) If a node goes down, you can no longer write to the cluster.
Read(2) + write(1) If a node goes down you can no longer read from the cluster AND you've lost data.
Write(2) + Read(2) Same effort as 3 node cluster. Why do 2?
Neither of these is ideal and the only advantage the 2 node cluster has over a 1 node 'cluster' is that if you're writing to all at least you don't lose data when a node dies.
Setup 2:
Ideally here you go with quorum, otherwise you're more likely to suffer outages.
Write(2) + Read(2) > RF Quorum (option 1) enables 1 node to die and your cluster to function as normal.
Write(3) + Read(1) > RF Write 3 allows you to only read from 1 node, speeding up reads at the cost of failing writes if a node becomes disconnected.
Write(1) + Read(3) > RF Read 3 Speeds up writes at the cost of losing data if a node goes down.