Instead of manually setting up your splits each time, try telling GDB which windows you want available.
For example:
;; Show main source buffer when using GDB
(setq gdb-show-main t)
Now you can simply use M-x gdb to start GDB, and it should keep your source code buffer displayed in a split window.
Incidentally, Emacs' GDB interface supports a number of other windows that you may want to enable:
If gdb-many-windows is non-nil, then M-x gdb displays the
following frame layout:
+--------------------------------+--------------------------------+
| GUD interaction buffer | Locals/Registers buffer |
|--------------------------------+--------------------------------+
| Primary Source buffer | I/O buffer for debugged pgm |
|--------------------------------+--------------------------------+
| Stack buffer | Breakpoints/Threads buffer |
+--------------------------------+--------------------------------+
If you ever change the window layout, you can restore the "many
windows" layout by typing M-x gdb-restore-windows. To toggle between
the many windows layout and a simple layout with just the GUD
interaction buffer and a source file, type M-x gdb-many-windows.
You may also specify additional GDB-related buffers to display,
either in the same frame or a different one. Select the buffers you
want by typing M-x gdb-display-BUFFERTYPE-buffer or M-x gdb-frame-BUFFERTYPE-buffer, where BUFFERTYPE is the relevant buffer
type, such as breakpoints. You can do the same with the menu bar,
with the GDB-Windows and GDB-Frames sub-menus of the GUD menu.
When you finish debugging, kill the GUD interaction buffer with C-x k,
which will also kill all the buffers associated with the session.
However you need not do this if, after editing and re-compiling your
source code within Emacs, you wish to continue debugging. When you
restart execution, GDB automatically finds the new executable. Keeping
the GUD interaction buffer has the advantage of keeping the shell
history as well as GDB's breakpoints. You do need to check that the
breakpoints in recently edited source files are still in the right
places.